Marc Guehi has returned to the Crystal Palace starting line-up after missing out last weekend in the 3-1 defeat at Aston Villa.
The defender, 22, was absent from the clash at Villa Park after picking up an injury on international duty with England.
Chris Richards has returned to the bench.
Jefferson Lerma is still missing with a hamstring injury, with Will Hughes starting back-to-back games.
Roy Hodgson has been forced to name two goalkeepers – Dean Henderson and Remi Matthews – in the matchday squad.
Crystal Palace: Johnstone, Ward, Andersen, Guehi, Mitchell, Hughes, Doucoure, Eze, Schupp, Edouard, Ayew.
Fulham: Leno, Reed, Jimenez, Ream, De Cordova-Reid, Pereira, Willian, Castagne, Palhinha, Diop, Robinson.
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