New genetic tests could predict risk for people with deadly heart condition

Doctors could soon begin offering patients and families personalised advice on their risk of developing a potentially deadly heart condition, new research says.

In a study published today, researchers showed that a risk score based on a person’s genetic profile could help predict the likelihood of them developing hypertrophic cardiomyopathy (HCM).

Those found to be at higher risk could be monitored more closely and offered treatments to reduce their risk of developing heart failure, abnormal heart rhythms, or cardiac arrest.  

The study was carried out by researchers from South Kensington’s Imperial College London alongside the MRC Laboratory of Medical Sciences, the University of Oxford, and Amsterdam University Medical Centre.

Professor James Ware, Professor at Imperial College London and co-lead of the study, said: “Our patients and their families want to know what the future holds after a diagnosis of HCM, but it is extremely difficult to advise because it is such a variable condition. 

“Thanks to this research, we’re an important step closer to being able to provide much needed clarity and reassurance.”

Around a third of HCM cases are caused by rare genetic faults in a single gene, usually inherited through families. 

But, this team of scientists discovered that ‘common genetic variants’ can also cause the condition.

Professor Metin Avkiran, director of International Partnerships and Special Programmes at the British Heart Foundation, said: “In HCM, an improved ability to predict which patients are likely to develop the disease and its complications, which can be life-threatening, would allow doctors to direct care accordingly. 

“In future, this could also support effective application of genetic therapies targeting a single faulty gene.”

Pictured top: Stock image (Picture: Pexels/Rdne)